Mrs. Sophia Duker, nee Debrah, was born on the 16th April 1942 in Koforidua in the Eastern region of Ghana. She was born into a strong Methodist family. Her parents were the Right Rev Moses Kwasi Debrah of Koforidua and Mrs. Mary Comfort Debrah of Effiduase, both in New Juaben.
Her grandfather, Opanyin Kwabena Debrah was a member of the team that went to Aburi to invite the Rev Thomas Birch Freeman to establish a Methodist Church in Koforidua. Her uncle, Opanyin Kwasi Agyei Debrah was a carpenter who roofed the present Wesley Cathedral in Koforidua. Her maternal grandparents were also Methodists and the family remained Methodist to date.